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The present study is aimed at evaluating serological method using scFv anti- Strongyloides  sp. and reporting the frequencies of the results with conventional parasitological technique (faeces) in elderly individuals. Among 112 elderly individuals (≥60 years of age), 14.28% were positive for at least one enteroparasite, with one individual positive for  S. stercoralis . Sera were evaluated for the presence of anti- Strongyloides  sp. antibodies using total or detergent fraction extracts of  Strongyloides venezuelensis , which presented positivity rates of 19.64% and 10.71%, respectively. An anti-HSP60 single-chain variable fragment from  Strongyloides  sp. was used to detect parasite antigens, with 5.36% (6 individuals) of ELISA-positive individuals returning a positive result. While the serological test indicates previous or recent infection and may be limited by antigen purification, the anti-HSP60 method reflects the presence of  Strongyloides  sp. immune complexes and exhibits greater sensitivity and specificity. Our results demonstrate the variable occurrence of enteroparasites in elderly individuals residing in long-term nursing homes and validate a novel epidemiological tool to describe infection cases by  Strongyloides  sp.

scFv against HSP60 of Strongyloides sp. and Its Application in the Evaluation of Parasite Frequency in the Elderly