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Doxorubicin  is an anthracycline antibiotic that is used for the treatment of various types of cancer. However, its clinical usage is limited due to its potential life-threatening adverse effects, such as cardio- and nephrotoxicities. Nonetheless, simultaneous administration of  doxorubicin  and antioxidants, such as those found in  green tea  leaves, could reduce cardiac and renal tissue damage caused by oxidative stress. The methylxanthine fraction isolated from  Bancha tea  leaves were tested  in vitro  for its antioxidant activity and  in vivo  for its organoprotective properties against  doxorubicin -induced cardio- and nephrotoxicities in a rat model. The  in vivo  study was conducted on male Wistar rats divided into 6 groups. Methylxanthines were administered at high (5 mg/kg body weight) and low (1 mg/kg body weight) doses, while doxorubicin was administered at a cumulative dose of 20 mg/kg body weight. Serum creatinine, uric acid, and urea concentrations, as well as serum enzyme levels (creatinine kinase (CK), creatinine kinase MB fraction (CK-MB), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH)) and electrolytes (Na + , K + , and Cl − ), were analysed. In addition, histological analysis was performed to assess cardiac and renal tissue damage. The concomitant administration of  Bancha  methylxanthines and  doxorubicin  showed a dose-dependent reduction in the serum biochemical parameters, indicating a decrease in the cardiac and renal tissue damage caused by the antibiotic. Histological analysis showed that pretreatment with methylxanthines at the dose of 5 mg/kg resulted in an almost normal myocardial structure and a significant decrease in the morphological kidney changes caused by  doxorubicin  exposure compared with the group that received  doxorubicin  alone. The putative mechanism is most likely related to a reduction in the oxidative stress caused by doxorubicin.

Protective Effect of Methylxanthine Fractions Isolated from Bancha Tea Leaves against Doxorubicin-Induced Cardio- and Nephrotoxicities in Rats