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Introduction   TCMI with the effect of  Liqihuoxue  and  Yiqihuoxue  has been applied as complementary therapies during the perioperative period of PCI for patients with ACS, while the recommended time points and plans of TCMI are still short of the support of evidence-based medicine.Methods   A systematic review and meta-analysis was conducted to evaluate the clinical efficacy and safety of TCMI on patients with ACS during the perioperative period of PCI. RCTs were searched based on standardized searching rules in seven medical databases from the inception up to August 2019. Two reviewers conducted the study selection, data extraction, and quality analysis independently. Data were analysed with the support of software  RevMan  and  Stata .Results   A total of 68 articles with 6,043 patients were enrolled. The result of meta-analysis showed that the TCMI combined with western medicine was superior to the western medicine alone on clinical efficiency (before the PCI, before and after the PCI, or overall,  P  < 0.05), the occurrence of MACE (myocardial infarction and stenocardia: before the PCI, before and after the PCI, or overall,  P  < 0.05; arrhythmia: before and after the PCI,  P  < 0.05), and the level of inflammatory factors (hs-CRP: before the PCI, before and after the PCI, or overall,  P  < 0.05; IL-6: after the PCI,  P  < 0.05). The TCMI with the effect of  Liqihuoxue  obtained more support compared with  Yiqihuoxue  based on the result of meta-analysis.Conclusions   TCMI with the effect of  Liqihuoxue  or  Yiqihuoxue  combined with western medicine generally showed the potential advantage on the treatment of ACS during the perioperative period of PCI. However, the optimal time point of intervention and recommended plan based on the effect still needs more clinical evidence. We consider that the research of precise and standardized application of TCMI will be a promising direction for TCM in the future.

evidence-based complementary and alternative medicine

The Application of Traditional Chinese Medicine Injection on Patients with Acute Coronary Syndrome during the Perioperative Period of Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials