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As the extant representatives of the basal chordate lineage, amphioxi (including the genera  Branchiostoma ,  Asymmetron  and  Epigonichthys ) play important roles in tracing the state of chordate ancestry. Previous studies have reported that members of the  Branchiostoma  species have similar morphological phenotypic characteristics, but in contrast, there are high levels of genetic polymorphisms in the populations. Here, we resequenced 20  Branchiostomabelcheri  genomes to an average depth of approximately 12.5X using the Illumina HiSeq 2000 platform. In this study, over 52 million variations (~12% of the total genome) were detected in the  B. belcheri  population, and an average of 12.8 million variations (~3% of the total genome) were detected in each individual, confirming that  Branchiostoma  is one of the most genetically diverse species sequenced to date. Demographic inference analysis highlighted the role of historical global temperature in the long-term population dynamics of  Branchiostoma , and revealed a population expansion at the Greenlandian stage of the current geological epoch. We detected 594 Single nucleotide polymorphism and 148 Indels in the  Branchiostoma  mitochondrial genome, and further analyzed their genetic mutations. A recent study found that the epithelial cells of the digestive tract in  Branchiostoma  can directly phagocytize food particles and convert them into absorbable nontoxic nutrients using powerful digestive and immune gene groups. In this study, we predicted all potential mutations in intracellular digestion-associated genes. The results showed that most “probably damaging” mutations were related to rare variants (MAF<0.05) involved in strengthening or weakening the intracellular digestive capacity of  Branchiostoma . Due to the extremely high number of polymorphisms in the  Branchiostoma  genome, our analysis with a depth of approximately 12.5X can only be considered a preliminary analysis. However, the novel variant dataset provided here is a valuable resource for further investigation of phagocytic intracellular digestion in  Branchiostoma  and determination of the phenotypic and genotypic features of  Branchiostoma .

Whole-Genome Resequencing of Twenty Branchiostoma belcheri Individuals Provides a Brand-New Variant Dataset for Branchiostoma