English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Purpose   The study was aimed at assessing renal functions of children with acute lymphoblastic leukemia (ALL) after induction therapy by  99m Tc-DTPA renal dynamic imaging Gates method (GFR Gates ) and investigating whether renal function after induction therapy will affect the occurrence of high-dose methotrexate- (HDMTX-) induced acute kidney injury (AKI).Methods   Children with newly diagnosed ALL were enrolled. Renal functions before the administration of HDMTX were assessed by estimated glomerular filtration rate (eGFR) and GFR Gates , respectively, before the first cycle of HDMTX after induction therapy. The areas under the ROC curve were used to assess covariates' ability to predict HDMTX-induced AKI.Results   102 children with ALL were included in the study. A stepwise backward binary logistic regression showed that only standardized GFR Gates  was an independent risk factor for HDMTX-induced AKI ( p  = 0.018, odds ratio 0.985, 95% CI 0.972-0.997). The area under the ROC of standardized GFR Gates  was 0.679 ( p  = 0.012, 95% CI 0.554-0.804).Conclusion   Standardized GFR Gates  showed that the normal renal function of children is not enough to be used as a cutoff point to predict HDMTX-induced AKI in ALL children receiving HDMTX. More attention and supportive care should be given to the children with standardized GFR Gates  lower than the cutoff value to avoid the HDMTX-induced AKI.

The Application of 99mTc-DTPA Renal Dynamic Imaging to Measuring Renal Function of Children with Acute Lymphoblastic Leukemia after Induction Therapy