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Background   Hyperuricemia is a risk factor for cardiovascular diseases, but the impact of hyperuricemia and sex-related disparities is not fully clear in elderly patients with acute coronary syndrome (ACS).Objective   To investigate the association between hyperuricemia and 1-year all-cause mortality in elderly patients with ACS.Methods   This retrospective cohort study included 711 consecutive ACS patients aged ≥75 years, hospitalized in our center between January 2013 and December 2017. Serum uric acid (sUA), in-hospital events, and 1-year follow-up were analyzed. Multivariable logistic regression models were used to explore the risk factors for in-hospital events and 1-year all-cause mortality.Results   sUA levels were higher in males than in females (381.4 ± 110.1 vs. 349.3 ± 119.1  μ mol/l,  P  < 0.001). Prevalence of hypertension (80.5% vs. 72.6%,  P  < 0.001). Prevalence of hypertension (80.5% vs. 72.6%,  P  < 0.001). Prevalence of hypertension (80.5% vs. 72.6%,  P  < 0.001). Prevalence of hypertension (80.5% vs. 72.6%,  P  < 0.001). Prevalence of hypertension (80.5% vs. 72.6%,  P  < 0.001). Prevalence of hypertension (80.5% vs. 72.6%,  P  < 0.001). Prevalence of hypertension (80.5% vs. 72.6%,  P  < 0.001). Prevalence of hypertension (80.5% vs. 72.6%,  P  < 0.001). Prevalence of hypertension (80.5% vs. 72.6%,Conclusions   Hyperuricemia is an independent risk factor for 1-year all-cause mortality in elderly female patients with ACS.

Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome