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Objective   To investigate whether the polymorphisms of interleukin-12B ( IL-12B ) were associated with the risk of developing colorectal cancer (CRC).  Patients and Methods . Genotypes of rs17860508 and rs3212227 were determined by polymerase chain reaction with a direct sequencing method in 329 CRC patients and 342 matched healthy control subjects. The expression of  IL-12B ) were associated with the risk of developing colorectal cancer (CRC).Results   Compared with TTAGAG/TTAGAG genotype of rs17860508, the GC/GC and TTAGAG/GC genotypes may significantly increase the risk of CRC (OR = 1.81, 95% CI = 1.18–2.78; OR = 1.46, 95% CI = 1.01–2.12, respectively). Furthermore, the mRNA levels of  IL-12B ) were associated with the risk of developing colorectal cancer (CRC).  P =0.009) and TTAGAG/TTAGAG ( P =0.009) and TTAGAG/TTAGAG (    Conclusion   These data suggested that the rs17860508 GC/GC genotype might upregulate  IL-12B  expression at the transcriptional level and thus increase the risk of CRC. IL-12B ) were associated with the risk of developing colorectal cancer (CRC).

A Functional Polymorphism in the Promoter Region of Interleukin-12B Increases the Risk of Colorectal Cancer