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Silver nanoparticles (Ag NPs) have become one of the current research hotspots and are used in many fields such as electrochemistry, energy, bioanalysis, and environmental monitoring, especially in the field of antibacterial research. In this study, we investigated the effect of properties of Ag NPs coated with polar materials. Ag NPs covered by a dispersant that was triethylene glycol monoethyl ether was stable and conquered the aggregation of Ag NPs. The effect of the dispersant on biocompatibility was explored through interaction experiments between Ag NPs and DNA sequence. The coated Ag NPs could adsorb DNA, and the fluorescence of FAM-DNA could be quenched by Ag NPs. The adsorption and desorption experiments of DNA showed that the order of DNA functional groups on the interaction process was phosphate>T>C>A>G. Moreover, we selected marine pathogenic bacteria to test the antibacterial effect of Ag NPs coated with a polar dispersant. The polar material had a certain inhibitory effect on the antibacterial activity of Ag NPs. However, small molecules such as bases could interact on the surface Ag NPs and release Ag+ to perform the antibacterial activity. The results could contribute to the further application of Ag NPs.

Effect of Properties of Silver Nanoparticles Coated with Polar Material and the Antibacterial Activity on Marine Pathogenic Bacteria