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Signal regulatory protein  α  (SIRP α ), a transmembrane protein that is predominantly expressed in dendritic cells (DCs) or macrophages, interacts with CD47 that is overexpressed in almost all types of tumor cells. The interaction between SIRP α  and CD47 leads to a negative signal that prevents the phenotypic and functional maturation of DC and inhibits phagocytosis. The SIRP α  knockdown in DCs that were pulsed with a modified HPV16E7 (HPV16mE7) protein with enhanced antigenicity and reduced transformation activity results in increased cytokine (TNF- α /IL-12/IL-6) secretion, IFN- γ  secretion by T lymphocytes, and  in vitro / in vivo  tumoricidal activity against cervical cancer cells. Taken together, these results suggest that SIRP α -silenced DC vaccination presented potential therapeutic implications against cervical cancer.

The Immunotherapeutic Effect of SIRPα-Silenced DCs against Cervical Cancer