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Objectives   Retina abnormalities are related to cognitive disorders in patients with Alzheimer's disease (AD). Retinal amyloid beta (A β ) can be labeled by curcumin. We measured A β  content in the cerebrum and retina of APPswe/PS1dE9 (APP) transgenic mice with early age to investigate the correlation between cerebrum and retina.Methods   APP mice and age-matched wild-type mice were investigated every month from age 2 months to 6 months to assess changes in A β  content in the retina and cerebrum. At the beginning of each month, mice were fed a curcumin diet (50 mg/kg/day) for 7 consecutive days. The A β  levels in the retina and cerebrum were measured by ELISAs. Correlations were identified between retinal and cerebral A β  contents using Pearson's correlation.Results   In the absence of curcumin, there was a significant correlation between A β  contents in the retina and cerebrum of APP mice ( r  = 0.7291,  P  = 0.0014). With increasing age, A β -mediated degenerative change in the cerebrum ( P  < 0.001 in 5 months) and retina ( P  < 0.01 in 5 months) increased significantly. The inhibitory effect of curcumin on the A β  level was significant in the cerebrum ( P  < 0.001) and retina ( P  < 0.01) of older APP mice in the early stage of life.Conclusion   We observed a significant correlation between the A β  content in the retina and A β  content in the cerebrum of APP mice. Our data suggest an appropriate time to measure retinal A β . Although curcumin can label A β  in the retina, it also suppresses A β  levels and weakens the degree of correlation between A β  in cerebrum and retina tissues.

behavioural neurology

Retinal Levels of Amyloid Beta Correlate with Cerebral Levels of Amyloid Beta in Young APPswe/PS1dE9 Transgenic Mice before Onset of Alzheimer’s Disease