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Purpose   To preliminarily evaluate the feasibility and potential of using  68 Ga-PSMA-11 PET/CT in evaluating the function of salivary glands and lacrimal glands in comparison with  99m Tc-pertechnetate ( 99m TcO 4  − ) salivary gland scintigraphy (SGS).Methods   A retrospective study was performed in 15 patients with different degrees of xerostomia and suspected salivary gland dysfunction. Each patient underwent  68 Ga-PSMA-11 PET/CT first and SGS the next day, and the findings of both scans were compared.Results   The results of  68 Ga-PSMA-11 PET/CT and SGS were consistent in 12/15 patients (80%) and were inconsistent in the remaining patients (20%). For 5 (33.3%) of 15 patients,  68 Ga-PSMA-11 PET/CT provided more information than did SGS. Additionally,  68 Ga-PSMA-11 PET/CT corrected the misdiagnosis by SGS for 1 patient.Conclusions    68 Ga-PSMA-11 PET/CT is a potentially useful imaging tool for evaluating the function of salivary glands and lacrimal glands.  68 Ga-PSMA-11 PET/CT can be a promising supplement to SGS, and its clinical value deserves further study.

contrast media and molecular imaging/contrast media and molecular imaging

Potential Applications of 68Ga-PSMA-11 PET/CT in the Evaluation of Salivary Gland Uptake Function: Preliminary Observations and Comparison with 99mTcO4− Salivary Gland Scintigraphy