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Aims   To compare the efficacy and safety of vonoprazan-based versus proton pump inhibitor (PPI)-based triple therapy in the eradication of  Helicobacter pylori .Methods   We performed a systematic search in PubMed, Embase, and the Cochrane Library databases for relevant randomized controlled trials up to March 2019. Studies were included if they compared the efficacy and safety of  H. pylori  eradication of vonoprazan-based and PPI-based triple therapy.Results   Three studies with 897 patients were evaluated in this meta-analysis. The  H. pylori  eradication rate of vonoprazan-based triple therapy was higher than that of PPI-based triple therapy as first-line regimens (intention-to-treat analysis: pooled eradication rates, 91.4% vs 74.8%; odds ratio [OR], 3.68; 95% confidence interval (CI): [1.87–7.26];  P <0.05). The incidence of adverse events in vonoprazan-based triple therapy was lower than that in PPI-based triple therapy (pooled incidence, 32.7% vs 40.5%; OR, 0.71; 95%CI: [0.53–0.95];  P <0.05).Conclusions   Efficacy of vonoprazan-based triple therapy is superior to that of PPI-based triple therapy for first-line  H. pylori  eradication. Additionally, vonoprazan-based triple therapy is better tolerated than PPI-based triple therapy.

biomed research international

Efficacy and Safety of Vonoprazan-Based versus Proton Pump Inhibitor-Based Triple Therapy for<i> Helicobacter pylori</i> Eradication: A Meta-Analysis of Randomized Clinical Trials

Efficacy and Safety of Vonoprazan-Based versus Proton Pump Inhibitor-Based Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Clinical Trials