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Multicenter sharing is an effective method to increase the data size for glioma research, but the data inconsistency among different institutions hindered the efficiency. This paper proposes a histogram specification with automatic selection of reference frames for magnetic resonance images to alleviate this problem (HSASR). The selection of reference frames is automatically performed by an optimized grid search strategy with coarse and fine search. The search range is firstly narrowed by coarse search of intraglioma samples, and then the suitable reference frame in histogram is selected by fine search within the sample selected by coarse search. Validation experiments are conducted on two datasets GliomaHPPH2018 and BraTS2017 to perform glioma grading. The results demonstrate the high performance of the proposed method. On the mixed dataset, the average AUC, accuracy, sensitivity, and specificity are 0.9786, 94.13%, 94.64%, and 93.00%, respectively. It is about 15% higher on all indicators compared with those without HSASR and has a slight advantage over the result of a manually selected reference frame by radiologists. Results show that our methods can effectively alleviate multicenter data inconsistencies and lift the performance of the prediction model.

Automatic Histogram Specification for Glioma Grading Using Multicenter Data