English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Purpose   To evaluate  CLU  polymorphisms in patients with pseudoexfoliation syndrome.Materials and Methods   We studied 81 patients (23 males and 58 females, the median age 76 years) and 91 control subjects (27 males and 64 females, the median age 75 years). Genotypes of the  CLU  polymorphisms (SNPs), rs3087554 and rs2279590, were determined using a commercially available validated genotyping assays. The  χ  2  test was performed to compare patient and control groups for possible associations between SNP genotype/allele frequency and disease state.Results   There were no significant differences for both allele and genotype frequencies between PEX patients and controls for rs3087554 and rs2279590 polymorphisms. The haplotypes distribution shows statistically significant difference between groups ( p =0.03). The haplotype (CT) more often was found in controls than in PEX patients, conferring an 18-fold decreased risk to the disease.Conclusion   Our results indicate that CLU variants may contribute to the risk of PEX in the Polish population.

CLU Polymorphisms in Patients with Pseudoexfoliation Syndrome in Polish Population