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A straightforward and high-yielding methodology for the synthesis of a high structural diversity of 1,2,4-oxadiazoles from different chiral N-protected α-amino acids and amidoximes under microwave (MW) irradiation is described herein. This greener approach gives the desired products using acetone/water as solvent in very short reaction times.

journal of chemistry

A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral <i>N</i>-Protected <i>α</i>-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach

A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach