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Purpose   The purpose of the current study was to evaluate the long-term functional results based on keratometric measurements, spherical and cylinder equivalent in patients with progressive keratoconus treated with conventional “epi-off” corneal collagen cross-linking (CXL).Methods   We conducted a retrospective study in which 113 eyes from 90 keratoconus-treated patients with CXL between 2006 and 2008 in Oculens Eye Clinic from Cluj-Napoca, Romania, were included. The diagnosis of keratoconus was based on corneal topography and its clinical signs. All patients were evaluated preoperatively, and a follow-up was performed at 1, 3, and 6 months and every year from 1 to 10 years after conventional CXL.Results   All keratometry measurements improved significantly during the follow-up. Compared to preoperative values, the improvement of  K  max  become statistically significant at 1 year after CXL (mean change compared to baseline −0.9 D,  p  < 0.001) and remained statistically significant thereafter up to 10 years (mean change compared to baseline −2.3 D,  p  < 0.001). As compared to preoperative values, mean spherical equivalent and mean cylinder improved during the follow-up, from a mean of −6.22 D before CXL to a mean value of −5.0 at 10 years, following CXL for spherical equivalent and from −4.4 D at baseline to −3.4 D at 10 years for cylinder ( p  < 0.05 for both). Uncorrected visual acuity increased, remaining statistically significant, by 0.104 logMAR at 10 years after CXL ( p =0.0015), and best-corrected visual acuity increased by 0.135 logMAR at 10 years after CXL ( p =0.015). We did not observe any case of severe complication.Conclusion   Our results show that CXL has a favorable effect on the progression of KC. The reduced  K  values, cylinder and spherical equivalent, and increased visual acuity remained the same 10 years after the procedure.

10-Year Results of Standard Cross-Linking in Patients with Progressive Keratoconus in Romania