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Background   Diabetes mellitus has become a major public health and economic problem across the globe. The inadequacies, as well as serious adverse effects associated with conventional medicines, led to a determined search for alternative natural therapeutic agents. The leaf latex extract of  Aloe megalacantha  has been used for the management of diabetes mellitus in Ethiopian folk medicine. This study aimed to evaluate the antidiabetic and antihyperlipidemic effects of the leaf latex extract of  A. megalacantha  in streptozotocin- (STZ-) induced diabetic model.Methods   The experimental diabetes was induced in Swiss albino mice by the administration of a single dose of STZ (150 mg/kg), intraperitoneally. The leaf latex extract of  A. megalacantha  at three different doses (100, 200, and 400 mg/kg) was administered for a period of 14 days. Fasting blood glucose levels (BGLs) were measured by glucose-oxidase and peroxidase reactive strips. After fourteen days, mice from all groups fasted and the blood was collected through puncturing the retroorbit of the eyes under mild anesthetic condition. The collected blood sample was used to determine serum biochemical parameters such as total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) cholesterol. The statistical analysis of results was carried out using one-way analysis (ANOVA) followed by post hoc multiple comparison tests.Results   Oral administration of  A. megalacantha  leaf latex extract at doses of 100, 200, and 400 mg/kg daily for 14 days results in a significant ( p < 0.05 ) decrease in fasting BGL as compared to negative control STZ-induced diabetic mice. The leaf latex has significantly reduced the level of TC, TG, and LDL, VLDL cholesterol while a significant ( p < 0.05 ) HDL cholesterol increment was observed.Conclusions   The findings of the present investigation indicated that the leaf latex of  A. megalacantha  possessed significant antihyperglycemic and antihyperlipidemic potential which may prove the claimed use of the plant in amelioration of diabetes and associated complications in Ethiopian folk medicine.

evidence-based complementary and alternative medicine

Antidiabetic and Antihyperlipidemic Activities of the Leaf Latex Extract of<i>Aloe megalacantha</i>Baker (Aloaceae) in Streptozotocin-Induced Diabetic Model

Antidiabetic and Antihyperlipidemic Activities of the Leaf Latex Extract ofAloe megalacanthaBaker (Aloaceae) in Streptozotocin-Induced Diabetic Model