English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective   The  NOCTURNIN  gene links nutrient absorption and metabolism to the circadian clock. Shift workers are at a heightened risk of overweight and of developing obesity and metabolic syndrome. This study investigates the diurnal variation of  NOCTURNIN  in healthy volunteers and its expression levels in rotational shift and daytime workers.MethodsNOCTURNIN  expression levels were evaluated in peripheral blood lymphocytes from 15 healthy volunteers at 4-hour intervals for 24 h. Metabolic parameters and  NOCTURNIN  expression were measured in workers engaged in shift and daytime work.Results   In the group of volunteers  NOCTURNIN  expression showed diurnal variation, with a peak at 8:00 AM.  NOCTURNIN  expression was higher in shift workers than in daytime workers. Multivariate analysis confirmed the role of shift work as an independent factor affecting  NOCTURNIN  expression. Notably, its level correlated directly with body mass index and inversely with total energy expenditure.Conclusions   Measuring  NOCTURNIN  expression levels in human peripheral blood lymphocytes can improve investigations on the relationship between changes in circadian rhythm and metabolic disorders. Shift workers show higher  NOCTURNIN  levels than daytime workers.

NOCTURNIN Gene Diurnal Variation in Healthy Volunteers and Expression Levels in Shift Workers