English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The present study aimed to assess the  in vitro  antibacterial and antibiotic modifying activities of methanol extracts prepared from the leaf (APL) and bark (APB) of  Acacia polyacantha , fractions (APLa-d) and compounds isolated from APL against a panel of multidrug resistant (MDR) Gram-negative bacteria. Leaf extract was subjected to column chromatography for compounds isolation; antibacterial assays were performed on samples alone and with an efflux pump inhibitor (EPI), respectively, and several antibiotics on the tested bacteria. The phytochemical investigation of APL led to the isolation of stigmasterol ( 1 ),  β -amyrin ( 2 ), 3- O-β - D -glucopyranosylstigmasterol ( 3 ), 3-O-methyl-D-chiro-inositol ( 4 ), epicatechin ( 5 ), quercetin-3- O -glucoside ( 6 ), 3- O -[ β - D -xylopyranosyl-(1→4)- β - D -galactopyranosyl]-oleanolic acid ( 7 ), and 3- O -[ β -galactopyranosyl-(1→4)- β - D -galactopyranosyl]-oleanolic acid ( 8 ). APL and APB had minimal inhibitory concentration (MIC) values ≤ 1024  μ g/mL on 73.3% and 46.7% of the tested bacteria, respectively. APLb and APLd were effective against 88.9% of tested bacterial species with compound 8 showing the highest activity inhibiting 88.9% of tested bacteria. The EPI, phenylalanine-arginine- β -naphthylamide (PAßN), strongly improved the activity of APL, APLb, APLd, and compound  8  on all tested bacteria. Synergistic effects were obtained when APL and compounds  7  and  8  were combined with erythromycin (ERY), gentamycin (GEN), ciprofloxacin (CIP), and norfloxacin (NOR). The present study demonstrates the antibacterial potential of  Acacia polyacantha  and its constituents to combat bacterial infections alone or in combination with EPI.

evidence-based complementary and alternative medicine

Antibacterial and Antibiotic Modifying Potential of Crude Extracts, Fractions, and Compounds from<i> Acacia polyacantha</i> Willd. against MDR Gram-Negative Bacteria

Antibacterial and Antibiotic Modifying Potential of Crude Extracts, Fractions, and Compounds from Acacia polyacantha Willd. against MDR Gram-Negative Bacteria