English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Rhus verniciflua  is widely known for its antioxidant, antibacterial, anticancer, and antiaging efficacy and  α -glucosidase inhibition. This study was designed whether  Rhus verniciflua  extracts inhibit the IgE-antigen-mediated allergic reaction in RBL-2H3 mast cells, and it further investigated the Fc ε RI- and arachidonate-signaling by which  Rhus verniciflua  extracts exert its antiallergic effects. IgE-antigen-sensitized RBL-2H3 mast cells were investigated for the cytotoxicity of  Rhus verniciflua  extracts and  β -hexosaminidase release, and inflammatory mediators (e.g., TNF- α , IL-4, IL-6, histamine, and PGD 2 ) were then assessed. Additionally, we examined expressions of genes involved in arachidonate- and Fc ε RI-signaling pathway in RBL-2H3.  Rhus verniciflua  extracts inhibited  β -hexosaminidase release and production of the inflammatory mediators in RBL-2H3.  Rhus verniciflua  extracts reduced amounts of histamine and expressions of Fc ε RI signaling-related genes such as Lyn and Syk and phosphorylation of extracellular signal-regulated kinase in mast cells. Finally, in late allergic responses,  Rhus verniciflua  extracts reduced PGD 2  release and COX-2 and cPLA2 phosphorylation expressions from IgE-antigen-mediated mast cells. Lastly, 250–500 mg/kg RVE significantly attenuated the Ag/IgE-induced passive cutaneous anaphylaxis (PCA) reaction in mice. These findings provide novel information on the molecular mechanisms underlying the antiallergy properties of  Rhus verniciflua  extracts in Fc ɛ RI-mediated allergic reaction.

evidence-based complementary and alternative medicine

Effect of<i>Rhus verniciflua</i>Extract on IgE-Antigen-Mediated Allergic Reaction in Rat Basophilic Leukemic RBL-2H3 Mast Cells and Passive Cutaneous Anaphylaxis in Mice

Effect ofRhus vernicifluaExtract on IgE-Antigen-Mediated Allergic Reaction in Rat Basophilic Leukemic RBL-2H3 Mast Cells and Passive Cutaneous Anaphylaxis in Mice