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Malaria is a devastating parasitic disease which caused around 216 million cases and 445,000 deaths worldwide in 2016. This might be attributed to a wide spread of drug resistant parasites. The plant  Aloe megalacantha  is indigenous to Ethiopia where the sap of the leaves is traditionally used for the treatment of malaria. This study was aimed at evaluating the antimalarial effect of leaf latex and isolates obtained from  Aloe megalacantha  against chloroquine sensitive  Plasmodium berghei  ANKA strain in Swiss albino mice. Peters' 4-day suppressive test method was used to test the antimalarial activity of both leaves latex and isolates. Three isolates were obtained using thin layer chromatography and were coded as AM 1 , AM 2 , and AM 3  in ascending order of their retention factor. After treatment of  Plasmodium berghei  infected mice with leaf latex of  Aloe megalacantha  for four days at 100, 200, and 400 mg/kg, it shows 30.3%, 43.4%, and 56.4% suppression of the parasite growth, respectively. 32.3%, 51.3%, and 67.4% chemosuppression after treatment with AM 1 , 39.8%, 50.6%, and 64.2% chemosuppression after treatment with AM 2 , and 52.6%, 69.4%, and 79.6% chemosuppression after treatment with AM 3  were observed at doses of 100, 200, and 400 mg/kg/day, respectively. The observed parasite suppression of leaves latex and isolates was statistically significant (P<0.05) as compared to negative control. Moreover, both the leaves latex and isolates were also observed to prevent  Plasmodium berghei  induced body weight loss and hypothermia and increased the survival time of  Plasmodium berghei  infected mice as compared to the negative control. Hence, the present study supports the traditional claim of the plant for the treatment of malaria.

Evaluation of Antimalarial Activity of the Leaf Latex and TLC Isolates from Aloe megalacantha Baker in Plasmodium berghei Infected Mice