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Most species of the genus  Elizabethkingia  are pathogenic to humans and animals, most commonly causing meningitis. However, our understanding of the pathogenic mechanisms involved is poor and there have been few pathological studies of  Elizabethkingia  spp. in animals. To understand the host injury induced by  Elizabethkingia  spp., we established a model of  E. miricola  infection in the black-spotted frog ( Pelophylax nigromaculatus ). The systematic pathology in and oxidative damage in the infection model were investigated. Our results show that recently isolated  E. miricola  is a bacterium that mainly parasitizes the host brain and that neurogenic organs are the predominant sites of damage. Infection mainly manifested as severe brain abscesses, meningoencephalitis, necrotic spondylitis, and necrotic retinitis. The liver, spleen, kidney, gastrointestinal tract, and lung were also affected to varying degrees, with bacterial necrotic inflammation.  P. nigromaculatus  also suffered enormous damage to its oxidative system during  E. miricola  infection, which may have further aggravated its disease state. Our results provide a preliminary reference for the study and treatment of  Elizabethkingia  spp. - induced neurological diseases in animals.

oxidative medicine and cellular longevity

Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus