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Objective   This study was to investigate the microbiological characteristics and the relationship between the time to positivity (TTP) of blood cultures and different bacterial species and to assess the clinical value of TTP in children with bloodstream infections (BSIs).Methods   The TTP of all the blood cultures from children with suspected BSIs was retrospectively collected in 2016. The microbiological characteristics and the relationship between the TTP of blood cultures and different bacterial species were also analyzed.Results   A total of 808 strains were isolated from 15835 blood cultures collected, and 145 (17.9%) were Gram-negative, 636 (78.7%) were Gram-positive, and 27 (3.3%) were fungi. The bacteria were divided into definite pathogens (174), possible pathogens (592), fungi (27), and contaminants (15). The average TTP of all positive blood cultures was 30.97 and ranged from 3.23 h to 92.73 h. The TTP of Gram-negative strains was significantly shorter than that of Gram-positive strains ( P  < 0.001) and fungi ( P  = 0.032). The mean TTP for  E. coli  (15.60 h) was shortest within the group of Gram-negative isolates, and the mean TTP for  Streptococcus  (17.34 h) within the group of Gram-positive isolates. Significant difference of the TTP was detected in methicillin-resistant vs methicillin-susceptible  S. aureus , extended-spectrum beta-lactamases (ESBLs) positive vs negative  Enterobacteriaceae , and extensive drug-resistant and non-XDR  A. baumannii . The median TTP in patients with BSI was significantly shorter than in those without it ( P  < 0.001). ROC curve analysis indicated that the TTP cutoff value of CoNS,  S. aureus ,  E. coli , and  K. pneumoniae  was 22.72 h, 19.6 h, 18.58 h, and 16.43 h, respectively, with most sensitive and specific predictor of BSIs.Conclusions   Our data acknowledged that TTP is a valuable index for the early prognosis of BSIs. TTP not only provides additional utility as a general predictor of bacteria with smear result but also provides the implication of drug-resistant organisms.

Value of Time to Positivity of Blood Culture in Children with Bloodstream Infections