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Medicinal plants have been identified as a feasible avenue for the development of new potent antidiabetic agents. The phytoconstituent compositions of different  Toona ciliata  and  Schkuhria pinnata  extracts were determined and quantified using standard chemical methods after exhaustive extraction. Thereafter, their antioxidant and antiglycation potentials were spectrophotometrically determined. The cytotoxicity profiles of the extracts on C2C12 cells were determined using the MTT assay.  Toona ciliata  methanol extract resulted in the highest percentage yield (20.83%) and high total phenols and flavonoids content in the methanol and acetone extracts compared to  S. pinnata  extracts. The acetone extract of  T. ciliata  showed good activity in the DPPH scavenging and FRAP assays with EC 50  values of 1.90 mg/ml and 5.26 mg/ml, respectively. Arbutin's antiglycation ability was outperformed by treatments with the methanol, acetone, and hexane extract of  T. ciliata  which resulted in 2.49%, 2.79%, and 2.56% glycation, respectively. The hexane extract of  T. ciliata  was less toxic to C2C12 cells as compared to the other extracts with CC 50  value of 402.16  μ g/ml. Only the hexane extract of  S. pinnata  resulted in glucose utilisation of 28.56% which was higher than that of insulin (26.06%) after 6 hours and is therefore considered as the most potent extract with hypoglycaemic potential in this study. Studies are ongoing aimed at identifying drug candidates in this extract that may be employed in the development of hypoglycaemic, antioxidant, and antiglycation agents.

evidence-based complementary and alternative medicine

Potential Antiglycation and Hypoglycaemic Effects of<i>Toona ciliata</i>M. Roem. and<i>Schkuhria pinnata</i>Lam. Thell. Crude Extracts in Differentiated C2C12 Cells

Potential Antiglycation and Hypoglycaemic Effects ofToona ciliataM. Roem. andSchkuhria pinnataLam. Thell. Crude Extracts in Differentiated C2C12 Cells