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Ligustrum robustum  is a traditional herbal tea that is widely distributed in southwest China. The health effects of  L. robustum  are characteristics of clearing heat, antioxidant, inducing resurgence, and improving digestion. However, the molecular mechanisms related to these effects, particularly the antioxidant mechanism, have been seldom reported. The objective of this study was to assess antioxidative capacity of  L. robustum , and its protective effects and mechanisms against hydrogen peroxide (H 2 O 2 ) - induced toxicity in Caco-2 cells. Total phenolic contents, free radical scavenging activity, and reducing capacity of  L. robustum  were measured. The effects of  L. robustum  on the cell viability and antioxidant defense system were explored. The expression of nuclear factor E2 related factor 2 (Nrf2) and antioxidant genes: quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1), and glutamate cysteine ligase (GCL) were analyzed by western blot and qPCR. Pretreatment of  L. robustum  could significantly reduce H 2 O 2 -induced toxicity, decrease the level of reactive oxygen species (ROS) and malondialdehyde (MDA), and increase the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione reductase (GR). By activating the expression of Nrf2 and antioxidant genes (NQO1, HO-1, and GCL),  L. robustum  exerts cytoprotective effect in Caco-2 cells dealt with H 2 O 2 . Therefore, the well-established model of Caco-2 cells demonstrates that  L. robustum  may modulate the cytoprotective effect against the H 2 O 2 -induced oxidative stress through the Nrf2 signaling pathway.

evidence-based complementary and alternative medicine

Cytoprotective Effect of<i> Ligustrum robustum</i> Polyphenol Extract against Hydrogen Peroxide-Induced Oxidative Stress via Nrf2 Signaling Pathway in Caco-2 Cells

Cytoprotective Effect of Ligustrum robustum Polyphenol Extract against Hydrogen Peroxide-Induced Oxidative Stress via Nrf2 Signaling Pathway in Caco-2 Cells