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Food borne pathogens cause serious human illnesses and diseases and their control using natural bioactive compounds becomes essential for the progress of agricultural and food industries. Developing novel tools to enhance the medicinal values of traditional horticultural medicinal crops is one of the promising methods for achieving food borne pathogens control. In this study, oligosaccharide water solutions were applied to  Heuchera  Creme Brulee and Mahogany subjected to a normal irrigation interval (2 days) or to prolonged irrigation intervals (6 days) for 6 weeks. Plant morphological, physiological, and metabolic markers associated with the bioactivity of leaf extracts against selected microbes. Oligosaccharide-treated plants showed significant increases in all morphological parameters during normal and prolonged irrigation intervals as compared to those of the controls. Morphological improvement associated with a significant increase in chlorophyll, carbohydrates, proline, K, Ca, phenols, and free and total ascorbate and antioxidants. Superoxide dismutase, catalase, and ascorbate peroxidase activities were higher, while H 2 O 2  accumulated to a lower extent in oligosaccharide-treated plants. These morphological and metabolic changes associated with increased antibacterial and antifungal activities of leaf extracts and their activities were comparable to antibiotics and antifungal agents (minimum inhibitory concentrations values were 0.5 -0.20 mg −1 mL for bacteria and 0.08 -0.20 mg −1 mL for fungi in Mahogany). The application of oligosaccharide and/or water stress might be of great value for producing natural bioactive compounds for food borne pathogens control.

HeucheraCreme Brulee and Mahogany Medicinal Value under Water Stress and Oligosaccharide (COS) Treatment