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We compared the functional outcome of Isl-1 +  cardiac progenitors, CD90 +  bone marrow-derived progenitor cells, and the combination of the two in a rat myocardial infarction (MI) model. Isl-1 +  cells were isolated from embryonic day 12.5 (E12.5) rat hearts and expanded in vitro. Thy-1 + /CD90 +  cells were isolated from the bone marrow of adult Sprague-Dawley rats by immunomagnetic cell sorting. Six-week-old female Sprague-Dawley rats underwent permanent left anterior descending (LAD) coronary artery ligation and received intramyocardial injection of either saline, Isl-1 +  cells, CD90 +  cells, or a combination of Isl-1 +  and CD90 +  cells, at the time of infarction. Cells were delivered transepicardially to the peri-infarct zone. Left ventricular function was assessed by transthoracic echocardiography at 1- and 4-week post-MI and by Millar catheterization (-dP/dt and +dP/dt) at 4-week post-MI. Fluorescence  in situ  hybridization (Isl-1 + cells) and monochrystalline iron oxide nanoparticles labeling (MION; CD90 +  cells) were performed to assess biodistribution of transplanted cells. Only the combination of cells demonstrated a significant improvement of cardiac function as assessed by anterior wall contractility, dP/dt (max), and dP/dt (min), compared to Isl-1 +  or CD90 +  cell monotherapies. In the combination cell group, viable cells were detected at week 4 when anterior wall motion was completely restored. In conclusion, the combination of Isl-1 +  cardiac progenitors and adult bone marrow-derived CD90 +  cells shows prolonged and robust myocardial tissue repair and provides support for the use of complementary cell populations to enhance myocardial repair.

Complementary Embryonic and Adult Cell Populations Enhance Myocardial Repair in Rat Myocardial Injury Model