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Aiweixin (AWX) is a traditional Uyghur medicine prescription, which has been used to treat senile diseases for a long time. We investigate whether the AWX extends the lifespan of  Caenorhabditis elegans . The AWX decoction was the conventional product for clinical use. The wild-type  Caenorhabditis elegans  (N2) and mutational worms,  daf-16(mu86), glp-1(e2141), daf-2(e1370),  and  eat-2(ad465),  were applied for the lifespan analysis. We found that the lifespan of the N2 adults' worm received 0.005 and 0.01 volume of AWX/total volume was extended significantly, compared to the control without treatment of AWX. The AWX at 0.01 volume of AWX/total volume significantly prolonged the life of both mutational worms,  daf-16 (mu86)  and  eat-2(ad465) , but did not increase the lifespan of the mutational worms,  daf-2(e1370)  and  glp-1(e2141) . These results indicated that the AWX significantly extended the lifespan of wild-type nematodes, and the life extension effect of AWX was related to the germline longevity pathway and IIS signaling pathway but independent of DAF-16/FOXO.

Aiweixin, a Traditional Uyghur Medicinal Formula, Extends the Lifespan of Caenorhabditis elegans