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Rhodomyrtus tomentosa , a flowering plant of Myrtaceae family from southern and southeastern Asia, was known to possess a rich source of structurally diverse and various biological activities. In this study, the inhibitory effect of  R. tomentosa  fruit extract (RFE) on allergic responses in calcium ionophore A23187-activated RBL-2H3 mast cells was investigated. The result showed that RFE was able to inhibit mast cell degranulation via decreasing  β -hexosaminidase release and intracellular Ca 2+  elevation at the concentration of 400  μ g/ml. Moreover, the suppressive effects of RFE on the production of interleukin-1 β  (IL-1 β ) and tumor necrosis factor- α  (TNF- α ) were evidenced. In addition, RFE effectively scavenged DPPH radical and suppressed the reactive oxygen species generation in a dose-dependent manner. Notably, the pretreatment of RFE caused the downregulation of tyrosine kinase Fyn phospholipid enzyme phospholipase C γ  (PLC γ ), extracellular-signal-regulated kinase (ERK), and nuclear factor kappa B (NF- κ B) phosphorylation. These results indicated that RFE could be a promising inhibitor of allergic responses and may be developed as bioactive ingredient for prevention or treatment of allergic diseases.

The Role of Rhodomyrtus tomentosa (Aiton) Hassk. Fruits in Downregulation of Mast Cells-Mediated Allergic Responses