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In this study, GC-MS analysis has shown that whole plant butanol fraction of  rheum ribes  (WBFRR) comprises of 21 compounds which exhibited anticancer (MCF-7) activity having IC 50  value of 36.01± 0.26. MTT assay (MCF-7), Oxidative Burst assay using chemiluminescence technique, and B-Hatching techniques were the methods used for anticancer MCF-7, anti-inflammatory, and Brine Shrimp Lethality Assay (BSLA). GC-MS was used for structural elucidation. Whole plant methanol extract of  rheum ribes  (WMERR), whole plant n-hexane fraction of  rheum ribes  (WHFRR), and whole plant aqueous fraction of  rheum ribes  (WAFRR) were inactive against anticancer (MCF-7) cell line. Whole plant methanol extract of  rheum ribes  (WMERR), whole plant aqueous fraction of  rheum ribes  (WAFRR) and whole plant butanol fraction of  rheum ribes  (WBFRR) showed anti-inflammatory activity on ROS having IC 50  value of 23.2±1.9, 24.2±2.7 and 12.0±0.6. Whole plant butanol fraction of  rheum ribes  (WBFRR) showed Brine Shrimp Lethality with LD50 693.302 while whole plant methanol extract of  rheum ribes  (WMERR) and whole plant aqueous fraction of  rheum ribes  (WAFRR) showed high lethality at highest concentration. This study revealed that whole plant butanol fraction of  rheum ribes  (WBFRR) exhibited significant anticancer (MCF-7) activity. In the near future, the constituent of whole plant butanol fraction of  rheum ribes  (WBFRR) can be the alternative drug against MCF-7 cell line with least toxicity and side effects.

biomed research international

In Vitro Anticancer MCF-7, Anti-Inflammatory, and Brine Shrimp Lethality Assay (BSLA) and GC-MS Analysis of Whole Plant Butanol Fraction of<i> Rheum ribes</i> (WBFRR)

In Vitro Anticancer MCF-7, Anti-Inflammatory, and Brine Shrimp Lethality Assay (BSLA) and GC-MS Analysis of Whole Plant Butanol Fraction of Rheum ribes (WBFRR)