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Aim.  To compare the effects of once-weekly Dulaglutide with once-daily glargine in poorly oral-antidiabetic controlled patients with type 2 diabetes mellitus (T2DM).  Method.  A total of 25 patients with T2DM admitted into Department of Endocrinology from December 2012 to August 2013 were randomly assigned into two groups: Dulaglutide group ( n  = 16) and glargine group ( n  = 9). All patients received either Dulaglutide or glargine treatments for 52 weeks. Continuous glucose monitoring systems (CGMS) were applied to them for two 72 h periods at before and after the treatment each. Patient general clinical data were collected and analyzed.  Result.  Fast blood glucose  ( FBG) of the glargine group declined more significantly than the Dulaglutide group after treatment ( p  < 0.05). The mean blood glucose (MBG), standard deviation of blood glucose (SDBG), mean amplitude of glycemic excursion (MAGE) within a day, the largest amplitude of glycemic excursion (LAGE),  M -value, absolute means of daily difference (MODD) of glycemic excursion, the percentage of time (≤2.8 mmol/L, ≤3.9 mmol/L, ≥10.0 mmol/L, ≥13.9 mmol/L, 3.9–7.8 mmol/L, and 9–10.0 mmol/L), maximum glycemic value, and minimum glycemic value were similar between the two groups ( p  > 0.05). The incidence of hypoglycemia was also similar between the two groups ( p  > 0.05). Though serum levels of TNF- α , IL-6, and 8-PGF2 α  all decreased, significant reduction was found in TNF- α  and 8-PGF2 α . TNF- α  was only significantly reduced in the Dulaglutide group, while 8-PGF2 α  was seen in both groups.  Conclusion.  For T2DM patients with poorly controlled oral antidiabetic drugs, once-weekly Dulaglutide not only has the same effect on glucose fluctuation as once-daily glargine but also significantly reduced TNF- α  and 8-PGF2 α  after a 52 week treatment protocol. This trial is registered with ClinicalTrials.gov  NCT01648582 .

biomed research international

The Effects of Once-Weekly Dulaglutide and Insulin Glargine on Glucose Fluctuation in Poorly Oral-Antidiabetic Controlled Patients with Type 2 Diabetes Mellitus