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Purpose   Associations between  XRCC1 ,  XRCC3 , and  ERCC2  gene polymorphism and prognosis have been investigated in several cancers. The aim of this meta-analysis was to assess the prognostic value of  XRCC1 ,  XRCC3 , and  ERCC2  gene polymorphism in hepatocellular carcinoma (HCC).Methods   A systematic literature search was performed to identify relevant studies in PubMed, Embase, and the Cochrane library up to December 2018. The prognostic values of  XRCC1 ,  XRCC3 , and  ERCC2  polymorphisms in HCC were estimated using crude HRs with 95% CIs.Results   Ten studies involving 2687 patients were included in the quantitative analysis. There were no statistically significant associations between  XRCC1  rs1799782 C>T,  XRCC1  rs25487 G>A, and  ERCC2  rs1799793 G>A polymorphisms and overall survival (OS). OS was significantly longer for the  ERCC2  rs13181 CC genotype than for AA (CC vs. AA: HR = 0.33, 95% CI = 0.15–0.72). A significantly lower OS was observed for patients with the CT genotype compared with the CC genotype at  XRCC3  rs861539 (CT vs. CC: HR = 1.64, 95% CI = 1.11–2.42).Conclusion   The  ERCC2  rs13181 A>C polymorphism and  XRCC3  rs861539 C>T polymorphism may be predictive markers for prognosis in patients with HCC. Well-designed studies with larger sample sizes are needed to verify our findings.

journal of oncology

A Comprehensive Evaluation of the Association between Polymorphisms in XRCC1, ERCC2, and XRCC3 and Prognosis in Hepatocellular Carcinoma: A Meta-Analysis