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Background   Liver injury has been recognized as a primary cause of hepatic morbidity and mortality.  Euscaphis konishii  Hayata, also called  Euscaphis fukienensis  Hsu, is usually used as a detumescent and analgesic agent to improve liver function in South China, but its mechanism of action and chemical composition are unclear.Objective   The main aim of the study was to investigate the constituent and potential hepatoprotective mechanism of the total triterpenes of  E. konishii  pericarp (TTEP).Methods  The constituent of TTEP was analyzed by a series of silica gel column to get single compounds and then identified by NMR and MS.  In vitro  assays were conducted to test the free radical scavenging activity of TTEP. The BCG/LPS-induced immunological livery injury mice model was established to clarify the hepatoprotective effect of TTEP  in vivo .Results   8 pentacyclic triterpene acids were separated and identified by NMR and MS. TTEP treatment (50, 100, and 200 mg/Kg) improved the immune function of the BCG/LPS-infected mice, dose-dependently alleviated the BCG/LPS-induced inflammation and oxidative stress, and ameliorated the hepatocyte apoptosis in the liver tissue.Conclusion   The pericarp of  E. konishii  may be further considered as a potent natural food for liver disease treatment.

evidence-based complementary and alternative medicine

Protective Effect of the Total Triterpenes of<i>Euscaphis konishii</i>Hayata Pericarp on Bacillus Calmette-Guérin Plus Lipopolysaccharide-Induced Liver Injury

Protective Effect of the Total Triterpenes ofEuscaphis konishiiHayata Pericarp on Bacillus Calmette-Guérin Plus Lipopolysaccharide-Induced Liver Injury