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Magnetic resonance (MR) imaging is a widely used imaging modality for detection of brain anatomical variations caused by brain diseases such as Alzheimer's disease (AD) and mild cognitive impairment (MCI). AD considered as an irreversible neurodegenerative disorder with progressive memory impairment moreover cognitive functions, while MCI would be considered as a transitional phase amongst age-related cognitive weakening. Numerous machine learning approaches have been examined, aiming at AD computer-aided diagnosis through employing MR image analysis. Conversely, MR brain image changes could be caused by different effects such as aging and dementia. It is still a challenging difficulty to extract the relevant imaging features and classify the subjects of different groups. This paper would propose an automatic classification technique based on feature decomposition and kernel discriminant analysis (KDA) for classifications of progressive MCI (pMCI) vs. normal control (NC), AD vs. NC, and pMCI vs. stable MCI (sMCI). Feature decomposition would be based on dictionary learning, which is used for separation of class-specific components from the non-class-specific components in the features, while KDA would be applied for mapping original nonlinearly separable feature space to the separable features that are linear. The proposed technique would be evaluated by employing T1-weighted MR brain images from 830 subjects comprising 198 AD patients, 167 pMCI, 236 sMCI, and 229 NC from the Alzheimer's disease neuroimaging initiative (ADNI) dataset. Experimental results demonstrate that classification accuracy (ACC) of 90.41%, 84.29%, and 65.94% can be achieved for classification of AD vs. NC, pMCI vs. NC, and pMCI vs. sMCI, respectively, indicating the promising performance of the proposed method.

computational and mathematical methods in medicine

A Classification Algorithm by Combination of Feature Decomposition and Kernel Discriminant Analysis (KDA) for Automatic MR Brain Image Classification and AD Diagnosis