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Background and Aims   The cag A and vac A genes of  Helicobacter pylori (H. pylori)  are closely associated with the pathogenicity of bacteria. However, the significance of H. pylori  babA, homB, aspA , and  sabA  genes is not clear in phenotypic characteristics of virulence. This study aimed to investigate the frequency and importance of these genes in patients with H. pylori positive peptic ulcer (PU).Materials and Methods   Patients with a PU or nonulcer dyspepsia (NUD) based on the upper gastrointestinal (UGI) endoscopy findings were included in the study. Biopsy samples from antrum and corpus were cultured into Columbia agar.  H pylori  were characterized by urease, catalase, oxidase test, and gram staining. Genomic DNA was extracted and stored. The  babA, homB, aspA , and  sabA  genes were determined by using polymerase chain reaction analysis.Results   A total 214 patients were included (99 PU and 115 NUD) and H. pylori could be isolated in 82 patients (36 PU and 46 NUD). The frequency of the  babA  (25% vs. 15.2%, p=0.25),  homB  (2.7% vs. 4.3%, p=1),  aspA  (69.4% vs. 73.9%, p=0.2), and  sabA  (2.7% vs. 10.8%, p=0.88) genotypes was not different between PU and NUD patients. There were some correlations between the presences of these genes.Conclusion   This study managed to determine  babA, homB, aspA,  and  sabA genes of  H. pylori by PCR. However, the frequency of these factors was not different in patients with PU and NUD. There is no role of  babA, homB, aspA , and  sabA genes  for the development of peptic ulcer in Turkish population.

The Prevalence of Helicobacter Pylori babA, homB, aspA, and sabA Genes and Its Relationship with Clinical Outcomes in Turkey