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Background and Aims   The NF- κ B pathway has been implicated in the genetic aetiology of psoriatic disease. However, since most patients with arthritis have psoriasis, discerning the genetic contributions to both aspects of psoriatic disease is not easy. Our aim was to study the association of common polymorphisms in genes of the NF- κ B pathway in patients with psoriatic disease in order to dissect the contribution of this pathway in the appearance of each component (skin and joint) of the disease.Patients and Methods   We investigated the association between three common variants in  NFKB1  (rs230526),  NFKBIA  (rs7152376), and  NFKBIZ  (rs3217713 indel) and the risk of developing psoriatic disease. We genotyped a total of 690 psoriatic disease patients and 550 controls. Patients with cutaneous psoriasis of at least 10 years of evolution without associated arthritis were defined to have pure cutaneous psoriasis (PCP).Results   The rare  NFKBIA  rs7152376 C was significantly more frequent in the PsA group vs. controls (OR = 2.03 (1.3–3.1),  p  < 0.01). The difference was even higher between PsA and PCP patients (OR = 3.2 (2.1–5.1),  p  < 0.001). Neither  NFKB1  rs230526 nor  NFKBIZ  rs3217713 indel was associated with the risk of developing psoriatic disease as a whole compared to controls.Conclusions   Our study supports a significant effect of the  NFKBIA  gene on the risk of developing PsA, thus contributing to better discerning of the polymorphisms of this pathway that explain this risk within the spectrum of psoriatic disease. Additional studies with larger cohorts and from different populations are necessary to validate these results.

biomed research international

Gene Variant in the NF-<i>κ</i>B Pathway Inhibitor <i>NFKBIA</i> Distinguishes Patients with Psoriatic Arthritis within the Spectrum of Psoriatic Disease

Gene Variant in the NF-κB Pathway Inhibitor NFKBIA Distinguishes Patients with Psoriatic Arthritis within the Spectrum of Psoriatic Disease