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Several studies have attributed the etiopathogenesis of chronic  Schistosoma mansoni  related hepatic fibrosis to unregulated immune responses against trapped parasite ova in the host. However, there is limited data on immune profiles associated with varying degrees of the disease in a population under chronic exposure to the parasite. We therefore investigated the role of selected T-helper (Th)1, Th2, and Th17 cytokines in relation to hepatic fibrosis severity among individuals resident in a hyper- Schistosoma mansoni  endemic region of Western Zambia. Two hundred and forty-four  S. mansoni  infected individuals with and without fibrosis were analysed for cytokine profiles. Based on hepatic fibrosis stage as determined by ultrasound, participants were categorized into Group 0, Group I, Group II, and Group III. Cytokines were measured in  S. mansoni  egg stimulated whole blood culture supernatants using the BD Cytometric Bead Array kits. Compared to the nonfibrotic group, participants in the severe hepatic fibrotic group produced less interleukin- (IL-) 6, IL-10, and tumour necrosis factor-alpha (TNF- α ). On the other hand, IL-13 was significantly elevated in this group compared to the nonfibrotic group ( p  < 0.001). Our results suggest that low IL-6, IL-10, and TNF- α  and high IL-13 levels may influence  S. mansoni  disease progression.

journal of parasitology research

Low IL-6, IL-10, and TNF-<i>α</i>and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in<i>Schistosoma mansoni</i>Chronically Exposed Individuals

Low IL-6, IL-10, and TNF-αand High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis inSchistosoma mansoniChronically Exposed Individuals