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Background . This study compared results of a study undertaken using Australia’s general practice electronic health record database, MedicineInsight, to assess risk of urinary-tract infections with sodium glucose cotransporter 2 inhibitors (SGLT2) for diabetes, by undertaking the same study in a 10% random sample of data from the national Pharmaceutical Benefits Scheme data.  Methods . Cohort studies were undertaken using deidentified data from the two national datasets. In each dataset, initiators of SGLT2 inhibitors were compared to initiators of dipeptidyl peptidase 4 (DPP-4) inhibitors in the period Jan 2012 to Sep 2015. The risk of urinary-tract infections (UTI) was assessed in six-month follow-up after initiation of SGLT2 and DPP-4.  Results . There were 1,977 people in the SGLT2 and 1,964 people in the DPP-4 cohort (MedicineInsight data) and 3,120 in the SGLT2 and 12,359 in the DPP-4 cohort (10% PBS data). In both datasets, the risk of UTI after initiation of SGLT2 was not significantly increased in comparison to DPP-4 cohort (MedicineInsight: 3.6% versus 4.9%; aHR=0.90, 95% CI 0.66-1.24; PBS: 3.0% versus 3.9%; aHR=0.90, 95% CI 0.72-1.13, 10%).  Conclusions . Comparison of MedicineInsight data to PBS national pharmacy data demonstrated highly comparable results for the specific study question. MedicineInsight is a reliable source of data that can be used for pharmacoepidemiological studies.

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Comparison of General Practice and Pharmaceutical Dispensing Data for Pharmacoepidemiological Research: Assessing the Risk of Urinary-Tract Infections with Sodium Glucose Cotransporter 2 Inhibitors for Diabetes