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Background. CrataBL  is a protein isolated from  Crataeva tapia  bark. It has been shown to exhibit several biological properties, including anti-inflammatory, analgesic, antitumor, and insecticidal activities. There are no studies evaluating the role of  CrataBL  in experimental asthma models.  Aim . To evaluate the effects of  CrataBL  on lung mechanics, inflammation, remodeling, and oxidative stress activation of mice with allergic pulmonary inflammation.  Materials and Methods . BALB/c mice (6-7 weeks old, 25-30g) were divided into four groups: nonsensitized and nontreated mice (C group, n=8); ovalbumin- (OVA-) sensitized and nontreated mice (OVA group, n=8); nonsensitized and  CrataBL -treated mice (C+CR group, n=8); OVA-sensitized and  CrataBL -treated mice (OVA+CR group, n=8). We evaluated hyperresponsiveness to methacholine, bronchoalveolar lavage fluid (BALF), pulmonary inflammation, extracellular matrix remodeling, and oxidative stress markers.  Results. CrataBL  treatment in OVA-sensitized mice (OVA+CR group) attenuated the following variables compared to OVA-sensitized mice without treatment (OVA group) (all p<0.05): (1) respiratory system resistance (Rrs) and elastance (Ers) after methacholine challenge; (2) total cells, macrophages, polymorphonuclear cells, and lymphocytes in BALF; (3) eosinophils and volume fraction of collagen and elastic fibers in the airway and alveolar wall according to histopathological and morphometry analysis; (4) IL-4-, IL-5-, IL-13-, IL-17-, IFN- γ -, MMP-9-, TIMP-1-, TGF- β -, iNOS-, and NF-kB-positive cells and volume of 8-iso-PGF2 α  in airway and alveolar septa according to immunohistochemistry; and (5) IL-4, IL-5, and IFN- γ  according to an ELISA.  Conclusion. CrataBL  contributes to the control of hyperresponsiveness, pulmonary inflammation, extracellular matrix remodeling, and oxidative stress responses in an animal model of chronic allergic pulmonary inflammation.

The Plant Proteinase InhibitorCrataBLPlays a Role in Controlling Asthma Response in Mice