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Objectives   The authors reported a retrospective study on myxoid liposarcomas (MLs), evaluating factors that may influence overall survival (OS), local recurrence-free survival (LRFS), metastasis-free survival (MFS), and analyzing the metastatic pattern.Methods   148 MLs were analyzed. The sites of metastases were investigated.Results   Margins ( p  = 0.002), grading ( p  = 0,0479), and metastasis ( p  < 0,0001) were significant risk factors affecting overall survival (OS). Type of presentation ( p  = 0.0243), grading ( p  = 0,0055), margin ( p  = 0.0001), and local recurrence (0.0437) were risk factors on metastasis-free survival (MFS). Authors did not observe statistically significant risk factors for local recurrence-free survival (LRFS) and reported 55% extrapulmonary metastases and 45% pulmonary metastases.Conclusion   Margins, grading, presentation, local recurrence, and metastasis were prognostic factors. Extrapulmonary metastases were more frequent in myxoid liposarcoma.

Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution