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Background   This study investigates the biological activities of  Anthyllis henoniana  flowers extracts.Materials and Methods   Antioxidant activity and the  in vitro  inhibitory effect of key digesting enzymes related to postprandial hyperglycemia were determined. Diabetic rats were orally and daily given the best extract from flowers of  Anthyllis henoniana  at a dose of acarbose for one month.Results   Among the extracts, the ethyl acetate one displayed remarkable antioxidant activity including DPPH (IC 50  = 2.34 mg/mL) and was more effective in inhibiting  α -glucosidase (IC 50  = 17  μ g/mL) than  α -amylase (IC 50  = 920  μ g /mL) activities.  In vivo , the results proved that ethyl acetate extract at doses of 400 mg/kg bw decreased significantly the blood glucose level and lipid profile levels and increased the activities of antioxidant enzymes. These protective impacts of  Anthyllis henoniana  ethyl acetate flowers extract were confirmed by histological results.Conclusion   This study demonstrates, for the first time, that  Anthyllis henoniana  flowers ethyl acetate extract is effective in inhibiting hyperglycemia and oxidative stress caused by diabetes.

evidence-based complementary and alternative medicine

Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Properties of<i>Anthyllis henoniana</i>(Coss.) Flowers Extracts in an Alloxan-Induced Rats Model of Diabetes

Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Properties ofAnthyllis henoniana(Coss.) Flowers Extracts in an Alloxan-Induced Rats Model of Diabetes