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Purpose   To evaluate the expression profiles of the VEGF α  and TGF β  in the ERMs and ILMs in retinal disorders.Methods   In this nonrandomized prospective study, 75 patients (34 females and 41 males) referred to pars plana vitrectomy (PPV) due to different retinal diseases were enrolled to the study. The samples of ERMs and ILMs collected during PPV were immediately put in TRIzol® Reagent (Life Technologies, USA) and stored at −70°C until RNA extraction. Gene expression analysis was done with TaqMan® Gene Expression Assays (Applied Biosystems, USA) following the manufacturer's instructions.Results   The gene expression levels of VEGF α  as well as of TGF β 2 were significantly higher in ERMs than in ILMs in all studied groups. The level of TGF β 2 expression exhibits a significantly lower values in iERMs as compared with the RRD group ( p  = 0.043). There were differences in TGF β 2 expression in ILM in groups studied: DR versus RRD,  p  = 0.003; DR versus iERM,  p  = 0,047; and iERM versus RRD,  p  = 0.004.Conclusions   Our results revealed that factors associated with angiogenesis and wound healing processes in eyes with RRD, PDR, iERM, and MH were more upregulated in ERMs than in ILMs. This may indicate that ILM is not responsible for reproliferation and its peeling should be avoided in routine PPV.

journal of ophthalmology

Evaluation of TGF-Beta 2 and VEGF<i>α</i> Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retinopathy, Macular Holes, and Idiopathic Epiretinal Membranes

Evaluation of TGF-Beta 2 and VEGFα Gene Expression Levels in Epiretinal Membranes and Internal Limiting Membranes in the Course of Retinal Detachments, Proliferative Diabetic Retinopathy, Macular Holes, and Idiopathic Epiretinal Membranes