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Background   We aimed to investigate the effect and mechanism of curcumin (CUR) in Alzheimer's disease (AD).Methods   Mouse hippocampal neuronal cell line HT-22 was treated with A β 1–42 and/or CUR, and then cell viability was evaluated by cell counting kit 8, Beclin-l level was detected using western blotting, and the formation of autophagosomes was observed by transmission electron microscopy (TEM). Furthermore, transcriptome sequencing and analysis were performed in cells with A β 1–42 alone or A β 1–42 + CUR.Results   A β 1–42 treatment significantly inhibited cell viability compared with untreated cells ( P  < 0.01). After treatment for 48 h, CUR remarkably promoted cell viability compared with cell treated with A β 1–42 alone ( P  < 0.01). Compared with cells treated with A β 1–42 alone, the expression of Beclin-1 was slightly reduced in cells with combined treatment of A β 1–42 with CUR ( P  < 0.05). Consistently, TEM results showed that CUR inhibited the formation of autophagosomes in cells treated with A β 1–42. Furthermore, the protein-protein interaction network showed five key genes, including MYC, Cdh1, Acaca, Egr1, and CCnd1, likely involved in CUR effects.Conclusions   CUR might have a potential neuroprotective effect by promoting cell viability in AD, which might be associated with cell autophagy. Furthermore, MYC, Cdh1, and Acaca might be involved in the progression of AD.

The Potential Protective Effect of Curcumin on Amyloid-β-42 Induced Cytotoxicity in HT-22 Cells