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The Raw  Curcumae Rhizoma  (R-CR), included in the  Chinese Pharmacopoeia Edition 2015 , is a well-known Chinese herbal medicine. However, the vinegar-processed  Curcumae Rhizoma  (V-CR) is used more widely than R-CR. The pharmacokinetics comparison of R-CR and V-CR after oral administration to rats is poorly understood. A novel method, rapid resolution liquid chromatography-tandem mass spectrometry (RRLC-MS) coupled with a sensitive, specific, and convenient microdialysis sampling method, free from endogenous interference was developed in this research. The extracts of R-CR and V-CR were administered orally to each group of rats. The blood and liver microdialysis probes were positioned within the jugular vein toward the right atrium and the median lobe near the center of the liver, respectively. Then, a double-peak phenomenon was observed in the concentration-time curves of curdione in R-CR group, while it was not observed in V-CR group. The liver-to-blood distribution ratio of curdione in V-CR group increased significantly ( P  < 0.05) compared to that of R-CR group. However, compared with V-CR group, the pharmacokinetic parameters of curcumol exhibited no statistically significant differences from those of R-CR group. These results indicate that vinegar-processed procedure has influence on the pharmacokinetic process of  Curcumae Rhizoma  in/ns. RRLC - MS coupled with microdialysis system could be used to evaluate the pharmacokinetics of typical constituents in  Curcumae Rhizoma  after oral administration.

evidence-based complementary and alternative medicine

Pharmacokinetic Comparisons of Typical Constituents in<i> Curcumae Rhizoma</i> and Vinegar-Processed<i> Curcumae Rhizoma</i> after Oral Administration to Rats

Pharmacokinetic Comparisons of Typical Constituents in Curcumae Rhizoma and Vinegar-Processed Curcumae Rhizoma after Oral Administration to Rats