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BackgroundDaodi  medicinal material is widely used in Chinese herb medication. However, there is a lack of systematic methodology for identifying characteristics associated with good quality and reliable efficacy of  Daodi  med-material.Purpose   The purpose of this study is to provide some evidence to further substantiate the use of  Daodi  medicinal materials.Methods   Seven relevant databases were searched before July 2014. Two evaluators were responsible for screening and categorizing the results. The data was analyzed with Microsoft Excel 2007 and SPSS 21.0 statistical software.Results   Overall, 107 articles were systematically analyzed. Of these studies, 55.1% (59/107) focused on the methodology to assess  Daodi  med-material, and 38.3% (41/107) were interested in med-material ingredients, soil physical and chemical properties, and the geological background system (GBS). Only 6.5% (7/107) of studies were mainly conducted as clinical trials and animal experiments.Conclusion   Comparisons between  Daodi  and non- Daodi  materials have been studied mainly in terms of the ingredients or composition of medical materials, soil physics and chemistry, and the GBS, and some identifying methodologies have been created to identify  Daodi  attributes. Until now, there is still no consensus of comparison criteria between  Daodi  and non- Daodi  medicinal material. Only a few studies were conducted through animal experiments and clinical trials to determine  Daodi  superiority.

Evidence-Based Study to Compare Daodi Traditional Chinese Medicinal Material and Non-Daodi Traditional Chinese Medicinal Material