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The Mediterranean diet is considered to prevent several diseases. In the present study, the antioxidant properties of six extracts from Mediterranean plant foods were assessed. The extracts' chemical composition analysis showed that the total polyphenolic content ranged from 56 to 408 GAE mg/g dw of extract. The major polyphenols identified in the extracts were quercetin, luteolin, caftaric acid, caffeoylquinic acid isomers, and cichoric acid. The extracts showed  in vitro  high scavenging potency against ABTS •+  and O 2   •−  radicals and reducing power activity. Also, the extracts inhibited peroxyl radical-induced cleavage of DNA plasmids. The three most potent extracts,  Cichorium intybus ,  Carthamus lanatus , and  Cichorium spinosum , inhibited OH • -induced mutations in  Salmonella typhimurium  TA102 cells. Moreover,  C. intybus ,  C. lanatus , and  C. spinosum  extracts increased the antioxidant molecule glutathione (GSH) by 33.4, 21.5, and 10.5% at 50  μ g/ml, respectively, in human endothelial EA.hy926 cells.  C. intybus  extract was also shown to induce in endothelial cells the transcriptional expression of Nrf2 (the major transcription factor of antioxidant genes), as well as of antioxidant genes  GCLC ,  GSR ,  NQO1 , and  HMOX1 . In conclusion, the results suggested that extracts from edible plants may prevent diseases associated especially with endothelium damage.

oxidative medicine and cellular longevity

Extracts from the Mediterranean Food Plants Carthamus lanatus, Cichorium intybus, and Cichorium spinosum Enhanced GSH Levels and Increased Nrf2 Expression in Human Endothelial Cells