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Objectives   To investigate whether  Panax ginseng  ( P. ginseng ) could affect the metabolism of Diester Alkaloids (DAs) derived from Aconiti Lateralis Radix in vivo.Methods and Results   24 male Sprague-Dawley rats were randomized for 7-day treatment with  P. ginseng  (low, middle, and high), or vehicle. Aconiti Lateralis Radix was administered orally to each group on the 8th day. Plasma samples were collected, and Xevo TQ-S was used to detect the concentration of aconitine, mesaconitine, and hypaconitine in plasma. We describe a fast and reproducible method to detect the concentration of aconitine, mesaconitine, and hypaconitine in plasma. Compared to the control group, the AUC (0-t)  of three DAs increased in both the middle and high dosing groups. The Vz/F of three DAs in these groups as well as the CLz/F of aconitine in all  P. ginseng  groups and the CLz/F of mesaconitine and hypaconitine in  P. ginseng  middle and high groups were decreased compared to the control group.Conclusion   Orally administrated  P. ginseng  potentially inhibits the metabolism of DAs from Aconiti Lateralis Radix in rats.

evidence-based complementary and alternative medicine

Simultaneous Evaluation of the Influence of<i> Panax ginseng</i> on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLC/QQQ-MS/MS

Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLC/QQQ-MS/MS