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The upper respiratory tract (URT) is home to various microbial commensals, which function as competitors to pathogens and help train the immune system. However, few studies have reported the normal microbiota carriage in the URT of healthy Chinese children. In this study, we performed a 16S rDNA gene sequencing analysis of 83 anterior nares (ANs), 60 nasopharynx (NP), and 97 oropharynx (OP) samples from 98 healthy children in Shenzhen, China (≤12 years of age). The microbiota in ANs and NP is the same at different ages and typical species in these sites include  Moraxella ,  Staphylococcus ,  Corynebacterium ,  Streptococcus , and  Dolosigranulum . By contrast, the OP is primarily colonized by  Streptococcus ,  Prevotella ,  Neisseria ,  Veillonella ,  Rothia ,  Leptotrichia , and  Haemophilus .  Streptococcus  and  Rothia  keep low abundance in OP microbiota of children  ≤ 1 year old, whereas  Prevotella ,  Neisseria ,  Haemophilus , and  Leptotrichia  amass significantly in individuals  > 1 year old. This work furnishes an important reference for understanding microbial dysbiosis in the URT of Chinese paediatric patients.

Microbiota Composition in Upper Respiratory Tracts of Healthy Children in Shenzhen, China, Differed with Respiratory Sites and Ages