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Mesenchymal stem/stromal cells (MSCs) are capable of migrating to sites of injury and inflammation in response to various cytokines to improve tissue repair. Previous studies have shown interferon-gamma (IFN- γ ) promoted migration of the V54/2 cell line and dental pulp stem cells (DPSCs), but the underlying mechanisms remain largely unknown. In this study, we found IFN- γ  induced migration and invasion of periodontal ligament stem cells (PDLSCs) in a dose-dependent manner  in vitro . While knockdown of guanylate-binding protein 1 (GBP1) suppressed IFN- γ -induced migration and invasion, ectopic expression of GBP1 potentiated IFN- γ -induced migration and invasion of PDLSCs. Furthermore, we demonstrated GBP1 was required for IFN- γ -induced processing of matrix metallopeptidase 2 (MMP2) in PDLSCs. Our findings indicate that GBP1 promotes IFN- γ -induced migration and invasion of PDLSCs by MMP2, and GBP1 may serve as a new target to facilitate MSC homing and migration.

Guanylate-Binding Protein 1 Promotes Migration and Invasion of Human Periodontal Ligament Stem Cells