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Brazilian ginseng, including  Pfaffia townsendii , is used in popular medicine as a natural anti-inflammatory, tonic, analgesic, and antidiabetic agent. In this study, we investigated the chemical composition and evaluated the antioxidant and anti-inflammatory activities of the  P. townsendii  ethanolic extract as well as the major isolated glycoside flavonoids tiliroside and patuletin 3-O- β -D-glucopyranoside. Chromatographic techniques and spectroscopic analysis were used for the isolation and identification of the major compounds. The antioxidant potential was determined through DPPH and ORAC-FL assays. The total phenolic content was measured using Folin-Ciocalteu reagent. The anti-inflammatory activity was determined based on a model of paw edema and carrageenan- (Cg-) induced pleurisy. We identified three phenolic acids, one carboxylic acid and two flavonoids, patuletin 3-O- β -D-glucopyranoside, and tiliroside. The ethanol crude extracts, partitions and isolated flavonoids (4581  μ mol of Trolox equivalents/g of extract in ORAC and a SC 50  of approximately 31.9  μ g/mL in the DPPH assay) demonstrated antioxidant activity, and the ethanolic extract as well as isolated flavonoids inhibited paw edema induced by Cg and leukocyte migration in the Cg-induced pleurisy model. The extract, tiliroside, and patuletin 3-O- β -D-glucopyranoside obtained from  P. townsendii  have therapeutic potential against oxidative stress-related and inflammatory disorders.

evidence-based complementary and alternative medicine

Anti-Inflammatory and Antioxidant Properties of the Extract, Tiliroside, and Patuletin 3-O-<i>β</i>-D-Glucopyranoside from<i> Pfaffia townsendii</i> (Amaranthaceae)

Anti-Inflammatory and Antioxidant Properties of the Extract, Tiliroside, and Patuletin 3-O-β-D-Glucopyranoside from Pfaffia townsendii (Amaranthaceae)